1. Download and install Docker Desktop

1. Access the Docker Desktop installation page.
2. Click Windows - x86_64to download the Docker Desktop installation file.
3. After running the installation file, check Use WSL 2 instead of Hyper-V and proceed with the installation.
   • During the installation, you may see the message "WSL 2 is not installed".

<aside> 💡

Why use Docker?

• The Trion GUI runs a high-performance engine**(GNINA**) for docking operations as a Docker container.
• This allows you to perform accurate simulations under the same conditions without any user configuration. </aside>

2. Install WSL 2 (if required)

1. Run PowerShell from the Start menu.

   

2. In PowerShell, type the command wsl --install.

   

3. After the installation is complete, restart your system.

4. If it still doesn't work, please refer to the post below.

   1. https://docs.docker.com/desktop/troubleshoot-and-support/troubleshoot/topics/#docker-desktop-fails-due-to-virtualization-not-working
   2. https://dslyh01.tistory.com/39

3. Verify Docker Desktop WSL backend settings

1. Run Docker Desktop.
2. Go to Settings > Resources > WSL Integration.
3. Make sure that the installed Ubuntu distribution is Enabled.

4. Run Docker Desktop

• You must run Docker Desktop before running Trion GUI.